VZV Varicella Zoster Virus

➤ What is VZV Varicella Zoster Virus?:

VZV Varicella Zoster Virus is a human specific herpesvirus which causes the highly contagious Chicken Pox. A patient who recovered from the infection may still be reinfected into adulthood as VZV Varicella Zoster Virus remains dormant in the nervous system. It may reactivate later in the form of Herpes Zoster (Shingles) or cause many other neurological conditions.

VZV Varicella Zoster Virus 101

➤ Other Names:
    • Human Herpesvirus Type 3
    • HHV-3
    • Chickenpox Virus
    • Varicella Virus
    • Zoster virus
    • Varicella-Zoster Virus VZV

Photo Credit: Creative Commons NIHGOV 2016
➤ VZV Varicella Zoster Virus Fast Facts:
    • Family: Herpesviridae
    • Sub-Family: Alphaherpesvirinae
    • Genus: Varicellovirus
    • Group: Group I
    • Species: Human HerpesVirus 3 (HHV-3)
    • Genome: (dsDNA)
    • Epidemilogy: Chicken Pox • Shingles
➤ History:
    Chicken Pox had been documented in ancient history. The commonality between Zoster and Chicken Pox was discovered in 1888. In addition, similiraties in viral particles between them were isolated by Ruska in 1943. The vaccine for Chicken Pox was introduced in 1974.
➤ Treatment:
    • Acyclovir for Chicken Pox
    • Famciclovir, Valaciclovir for Shingles
    • Zoster-Immune Globulin (ZIG)
    • Vidarabine
    • VZV Immune Globulin

VZV Varicella Zoster Virus Risk Factors

➤ Virus Latency:
    10–20% of cases reactivate in adulthood
➤ Remains Dormant in:
    • Nerves
    • Cranial Nerve Ganglia
    • Dorsal Root Ganglia
    • Autonomic Ganglia
➤ Complications:
    • Postherpetic Neuralgia
    • Mollaret’s Meningitis
    • Zoster Multiplex
    • Inflammation of arteries in the brain (Stroke)
    • Myelitis
    • Herpes Ophthalmicus
    • Zoster Sine Herpete
    • Ramsay Hunt Syndrome

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